Agitation Psychopharmacology
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| Generic (Route) | Brand | Initial Dose (mg) | Max Total Daily Dose (mg) | Time to Max Concentration (min) | Time Before Repeat Administration (min) |
|---|---|---|---|---|---|
| Oral | |||||
| Risperidone (PO) | Risperdal® | 2 | 6 | 60 | 120 |
| Olanzapine (PO) | Zyprexa® | 5 – 10 | 20 | 360 | 120 |
| Haloperidol (PO)* | Haldol® | 5 | 20 | 30 – 60 | 15 |
| Lorazepam (PO) | Ativan® | 2 | 12 | 20 – 30 | 120 |
| Intramuscular | |||||
| Lorazepam (IM) | Ativan® | 2 | 12 | 20 – 30 | 120 |
| Ziprasidone (IM) | Geodon® | 10 | 40 | 15 | 120 |
| Ziprasidone (IM) | Geodon® | 20 | 40 | 15 | 240 |
| Olanzapine (IM) | Zyprexa® | 5 – 10 | 30 | 15 – 45 | 20 |
| Aripiprazole (IM) | Abilify® | 9.75 | 30 | 60 | 120 |
| Haloperidol (IM)* | Haldol® | 5 | 20 | 30 – 60 | 15 |
| Intravenous | |||||
| Haloperidol (IV)*† | Haldol® | 2 – 5 | 10 | 0 | 240 |
| * Likely to cause higher incidence of extrapyramidal side effects than other recommended drugs | |||||
| † Administering haloperidol intravenously increases risk of QT prolongation. Avoid if possible, especially in patients w/ borderline QT or taking other medication that can prolong QT. If given IV, limit dose and provide cardiac monitoring. | |||||
Dosing
Timing
References
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